To execute their filtration function, podocytes have to develop and maintain an incredible complex and polarized three-dimensional architecture. The signal mechanisms necessary to establish and maintain the structure and orientation of the foot process network are largely unknown. However, these developmental programs seem to reappear during podocyte stress, most likely in a dysregulated fashion.

Combining genome wide expression screens with transgenic mouse models, kidney cultures and C. elegans models we aim to elucidate the developmental mechanisms that regulate the formation of the glomerular structure. Our recent results indicate the unique polarity of podocytes and identify the PAR polarity complex as a critical regulator of podocyte morphogenetic changes during development and disease.