Glomerular kidney diseases are of major public health importance not only because of their high prevalence, but also because they are a major independent risk factor for cardiovascular morbidity and mortality. Despite the crucial importance of the kidney both as a target and as determinant of human disease, knowledge of the molecular networks underlying glomerular development, regeneration and diseases is very limited. Our studies aim to elucidate molecular programs that will help to formulate therapeutic interventions that delay the onset and progression of glomerular diseases.

Our research focuses on four main topics:

1. Mechanisms of glomerular development.
2. Slit diaphragm signalling and Neph1-Nephrin protein biology.
3. Signalling networks regulating kidney regeneration and glomerular aging.
4. mTor signalling in polycystic kidney disease.