Publications

Chubanov V, Köttgen M, Touyz RM, Gudermann T. (2024) TRPM channels in health and disease. Nat Rev Nephrol, doi: 10.1038/s41581-023-00777-y.
Patil S, Borisov O, Scherer N, Wirth C, Schlosser P, Wuttke M, Ehret S, Hannibal L, Eckardt KU, Hunte C, Neubauer B, Köttgen A, Köttgen M. (2024) The membrane transporter SLC25A48 enables transport of choline into human mitochondria. Kidney Int, doi: 10.1016/j.kint.2024.06.022. Epub ahead of print.
Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, Steinbrenner I, Uluvar B, Wuttke M, Cheng Y, Ekici AB, Gyimesi G, Karoly ED, Kotsis F, Mielke J, Gomez MF, Yu B, Grams ME, Coresh J, Boerwinkle E, Köttgen M, Kronenberg F, Meiselbach H, Mohney RP, Akilesh S; GCKD Investigators; Schmidts M, Hediger MA, Schultheiss UT, Eckardt KU, Oefner PJ, Sekula P, Li Y, Köttgen A. (2023) Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine. Nat Genet, doi: 10.1038/s41588-023-01409-8.
Lang K, Milosavljevic J, Heinkele H, Chen M, Gerstner L, Spitz D, Kayser S, Helmstädter M, Walz G, Köttgen M, Spracklen A, Poulton J, Hermle T. (2022) Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes. Elife, doi: 10.7554/eLife.79037.
Westermann L, Li Y, Göcmen B, Niedermoser M, Rhein K, Jahn J, Cascante I, Schöler F, Moser N, Neubauer B, Hofherr A, Behrens YL, Göhring G, Köttgen A, Köttgen M, Busch T. (2022) Wildtype heterogeneity contributes to clonal variability in genome edited cells. Sci Rep, doi: 10.1038/s41598-022-22885-8.
Kumar P, Zadjali F, Yao Y, Köttgen M, Hofherr A, Gross KW, Mehta D, Bissler JJ. (2022) Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking. Biology (Basel), doi: 10.3390/biology11050709.
Friedrich S, Müller H, Riesterer C, Schüller H, Friedrich K, Wörner CL, Busch T, Viau A, Kuehn EW, Köttgen M, Hofherr A. (2021) Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia. Sci Rep, doi: 10.1038/s41598-021-94442-8.
Peintner L, Venkatraman A, Waeldin A, Hofherr A, Busch T, Voronov A, Viau A, Kuehn EW, Köttgen M, Borner C. (2021) Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner Autophagy, doi: 10.1080/15548627.2020.1826716.
Westermann L, Neubauer B, Köttgen M. (2021) Nobel Prize 2020 in Chemistry honors CRISPR: a tool for rewriting the code of life. Pflugers Arch, doi: 10.1007/s00424-020-02497-9.
Köttgen A, Köttgen M. (2021) A novel mouse model of hyperuricemia expressing a human functional ABCG2 variant. Kidney Int, doi: 10.1016/j.kint.2020.10.021.
Schlosser P, Li Y, Sekula P, Raffler J, Grundner-Culemann F, Pietzner M, Cheng Y, Wuttke M, Steinbrenner I, Schultheiss UT, Kotsis F, Kacprowski T, Forer L, Hausknecht B, Ekici AB, Nauck M, Völker U; GCKD Investigators, Walz G, Oefner PJ, Kronenberg F, Mohney RP, Köttgen M, Suhre K, Eckardt KU, Kastenmüller G and Köttgen A. (2020) Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans Nat Genet, doi: 10.1038/s41588-019-0567-8.
Tosic J, Kim GJ, Pavlovic M, Schröder CM, Mersiowsky SL, Barg M, Hofherr A, Probst S, Köttgen M, Hein L and Arnold SJ. (2020) Author Correction: Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state Nat Cell Biol, doi: 10.1038/s41556-019-0452-9.
Fixemer J, Hummel JF, Arnold F, Klose CSN, Hofherr A, Weissert K, Kögl T, Köttgen M, Arnold SJ, Aichele P, Tanriver Y. (2020) Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells PLoS Pathog, doi: 10.1371/journal.ppat.1008870.
Tosic J, Kim GJ, Pavlovic M, Schröder CM, Mersiowsky SL, Barg M, Hofherr A, Probst S, Köttgen M, Hein L and Arnold SJ. (2019) Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state Nat Cell Biol, doi: 10.1038/s41556-019-0423-1.
Dumit VI, Köttgen M and Hofherr A. (2019) Mass Spectrometry-Based Analysis of TRPP2 Phosphorylation Methods Mol Biol., doi: 10.1007/978-1-4939-9446-5_4.
Hofherr A, Busch T and Köttgen M. (2018) HIF-1alpha drives cyst growth in advanced stages of autosomal dominant polycystic kidney disease Kidney Int, doi: 10.1016/j.kint.2018.07.012.
Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A, Wakimoto B, Schütze C, Wiedemann N, Artati A, Adamski J, Walz G, Kunji ERS, Montell C, Watnick T and Köttgen M. (2018) The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism PLoS Biol, doi: 10.1371/journal.pbio.2005651.
Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI, Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A and Kuehn EW. (2018) Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney EMBO J, doi: 10.15252/embj.201798615.
Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaimé F, Kuehn EW, Arnold SJ and Köttgen M. (2017) Efficient genome editing of differentiated renal epithelial cells Pflugers Arch, doi: 10.1007/s00424-016-1924-4.
Busch T, Köttgen M and Hofherr A. (2017) TRPP2 ion channels: Critical regulators of organ morphogenesis in health and disease Cell Calcium, doi: 10.1016/j.ceca.2017.05.005.
Cabezas OR, Flanagan SE, Stanescu H, ..., Köttgen M, ..., Hussain K, Ellard S and Bockenhauer D. (2017) Polycystic Kidney Disease with Hyperinsulinemic Hypoglycemia Caused by a Promoter Mutation in Phosphomannomutase 2. J Am Soc Nephrol, doi: 10.1681/ASN.2016121312.
Hofherr A and Köttgen M. (2016) Polycystic kidney disease: Cilia and mechanosensation revisited Nat Rev Nephrol, doi: 10.1038/nrneph.2016.61.
Hofherr A, Wagner CJ, Watnick T and Köttgen M. (2016) Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition Kidney Int, doi: 10.1016/j.kint.2015.11.015.
M. Semmo, M. Kottgen and A. Hofherr (2014) The TRPP subfamily and polycystin-1 proteins Handb Exp Pharmacol 222, 675-711
A. Hofherr, C. Wagner, S. Fedeles, S. Somlo and M. Kottgen (2014) N-glycosylation determines the abundance of the transient receptor potential channel TRPP2 J Biol Chem 289, 14854-67
A. Hofherr and M. Kottgen (2013) Induced pluripotent stem cells from polycystic kidney disease patients: a novel tool to model the pathogenesis of cystic kidney disease J Am Soc Nephrol 24, 1507-9
O. M. Woodward, D. N. Tukaye, J. Cui, P. Greenwell, L. M. Constantoulakis, B. S. Parker, A. Rao, M. Kottgen, P. C. Maloney and W. B. Guggino (2013) Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules Proc Natl Acad Sci U S A 110, 5223-8
A. Tin; O. M. Woodward; W. H. Kao; C. T. Liu; X. Lu; M. A. Nalls; D. Shriner; M. Semmo; E. L. Akylbekova; S. B. Wyatt; S. J. Hwang; Q. Yang; A. B. Zonderman; A. A. Adeyemo; C. Palmer; Y. Meng; M. Reilly; M. G. Shlipak; D. Siscovick; M. K. Evans; C. N. Rotimi; M. F. Flessner; M. Kottgen; L. A. Cupples; C. S. Fox; A. Kottgen (2011) Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele Hum Mol Genetâ? 20,â? 4056-68.
A. Tin, O. M. Woodward, W. H. Kao, C. T. Liu, X. Lu, M. A. Nalls, D. Shriner, M. Semmo, E. L. Akylbekova, S. B. Wyatt, S. J. Hwang, Q. Yang, A. B. Zonderman, A. A. Adeyemo, C. Palmer, Y. Meng, M. Reilly, M. G. Shlipak, D. Siscovick, M. K. Evans, C. N. Rotimi, M. F. Flessner, M. Kottgen, L. A. Cupples, C. S. Fox and A. Kottgen (2011) Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele Hum Mol Genet 20, 4056-68
M. Kottgen; A. Hofherr; W. Li; K. Chu; S. Cook; C. Montell; T. Watnick (2011) Drosophila Sperm Swim Backwards in the Female Reproductive Tract and Are Activated via TRPP2 Ion Channels PLoS Oneâ? 6,â? e20031.
M. Kottgen, A. Hofherr, W. Li, K. Chu, S. Cook, C. Montell and T. Watnick (2011) Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels PLoS One 6, e20031
O. M. Woodward; A. Kottgen; M. Kottgen (2011) ABCG transporters and disease FEBS J.
O. M. Woodward, A. Kottgen and M. Kottgen (2011) ABCG transporters and disease Febs J 278, 3215-25
A. Hofherr; M. Kottgen (2011) TRPP channels and polycystins Adv Exp Med Biolâ? 704,â? 287-313.
A. Hofherr and M. Kottgen (2011) TRPP channels and polycystins Adv Exp Med Biol 704, 287-313
M. Kottgen; T. Benzing (2011) Strangers on a train: atypical glutamate receptors in the kidney glomerulus. Focus on "Functional NMDA receptors with atypical properties are expressed in podocytes" Am J Physiol Cell Physiolâ? 300,â? C9-10.
M. Kottgen and T. Benzing (2011) Strangers on a train: atypical glutamate receptors in the kidney glomerulus. Focus on "Functional NMDA receptors with atypical properties are expressed in podocytes" Am J Physiol Cell Physiol 300, C9-10
C. Boehlke; F. Kotsis; V. Patel; S. Braeg; H. Voelker; S. Bredt; T. Beyer; H. Janusch; C. Hamann; M. Godel; K. Muller; M. Herbst; M. Hornung; M. Doerken; M. Kottgen; R. Nitschke; P. Igarashi; G. Walz; E. W. Kuehn (2010) Primary cilia regulate mTORC1 activity and cell size through Lkb1 Nat Cell Biolâ? 12,â? 1115-22.
O. M. Woodward; A. Kottgen; J. Coresh; E. Boerwinkle; W. B. Guggino; M. Kottgen (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout Proc Natl Acad Sci U S Aâ? 106,â? 10338-42.
T. Wegierski; D. Steffl; C. Kopp; R. Tauber; B. Buchholz; R. Nitschke; E. W. Kuehn; G. Walz; M. Kottgen (2009) TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum EMBO Jâ? 28,â? 490-9.
M. Kottgen; B. Buchholz; M. A. Garcia-Gonzalez; F. Kotsis; X. Fu; M. Doerken; C. Boehlke; D. Steffl; R. Tauber; T. Wegierski; R. Nitschke; M. Suzuki; A. Kramer-Zucker; G. G. Germino; T. Watnick; J. Prenen; B. Nilius; E. W. Kuehn; G. Walz (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex J Cell Biolâ? 182,â? 437-47.
Y. Wang; X. Fu; S. Gaiser; M. Kottgen; A. Kramer-Zucker; G. Walz; T. Wegierski (2007) OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum J Biol Chemâ? 282,â? 36561-70.
M. Kottgen (2007) TRPP2 and autosomal dominant polycystic kidney disease Biochim Biophys Actaâ? 1772,â? 836-50.
S. J. Moon; M. Kottgen; Y. Jiao; H. Xu; C. Montell (2006) A taste receptor required for the caffeine response in vivo Curr Biolâ? 16,â? 1812-7.
B. Schermer; K. Hopker; H. Omran; C. Ghenoiu; M. Fliegauf; A. Fekete; J. Horvath; M. Kottgen; M. Hackl; S. Zschiedrich; T. B. Huber; A. Kramer-Zucker; H. Zentgraf; A. Blaukat; G. Walz; T. Benzing (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia EMBO Jâ? 24,â? 4415-24.
M. Kottgen; G. Walz (2005) Subcellular localization and trafficking of polycystins Pflugers Archâ? 451,â? 286-93.
M. Kottgen; T. Benzing; T. Simmen; R. Tauber; B. Buchholz; S. Feliciangeli; T. B. Huber; B. Schermer; A. Kramer-Zucker; K. Hopker; K. C. Simmen; C. C. Tschucke; R. Sandford; E. Kim; G. Thomas; G. Walz (2005) Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation EMBO Jâ? 24,â? 705-16.
B. Buchholz; R. Tauber; D. Steffl; G. Walz; M. Kottgen (2004) An inwardly rectifying whole cell current induced by Gq-coupled receptors Biochem Biophys Res Communâ? 322,â? 177-85.
M. Kottgen; T. Loffler; C. Jacobi; R. Nitschke; H. Pavenstadt; R. Schreiber; S. Frische; S. Nielsen; J. Leipziger (2003) P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport J Clin Investâ? 111,â? 371-9.
T. Benzing; M. Kottgen; M. Johnson; B. Schermer; H. Zentgraf; G. Walz; E. Kim (2002) Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha J Biol Chemâ? 277,â? 32954-62.
T. B. Huber; M. Kottgen; B. Schilling; G. Walz; T. Benzing (2001) Interaction with podocin facilitates nephrin signaling J Biol Chemâ? 276,â? 41543-6.
T. von Hahn; I. Thiele; L. Zingaro; K. Hamm; M. Garcia-Alzamora; M. Kottgen; M. Bleich; R. Warth (2001) Characterisation of the rat SK4/IK1 K(+) channel Cell Physiol Biochemâ? 11,â? 219-30.
R. Nitschke; A. Henger; S. Ricken; V. Muller; M. Kottgen; M. Bek; H. Pavenstadt (2001) Acetylcholine increases the free intracellular calcium concentration in podocytes in intact rat glomeruli via muscarinic M(5) receptors J Am Soc Nephrolâ? 12,â? 678-87.
M. Kottgen; A. Hoefer; S. J. Kim; U. Beschorner; R. Schreiber; M. J. Hug; R. Greger (1999) Carbachol activates a K+ channel of very small conductance in the basolateral membrane of rat pancreatic acinar cells Pflugers Archâ? 438,â? 597-603.
M. Kottgen; A. E. Busch; M. J. Hug; R. Greger; K. Kunzelmann (1996) N-Acetyl-L-cysteine and its derivatives activate a Cl- conductance in epithelial cells Pflugers Archâ? 431,â? 549-55.
M. Bleich; M. Kottgen; E. Schlatter; R. Greger (1995) Effect of NH4+/NH3 on cytosolic pH and the K+ channels of freshly isolated cells from the thick ascending limb of Henle's loop Pflugers Archâ? 429,â? 345-54.
M. Kottgen; J. Leipziger; K. G. Fischer; R. Nitschke; R. Greger (1994) pH regulation in HT29 colon carcinoma cells Pflugers Archâ? 428,â? 179-85.
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