Publications

T. B. Huber; G. Walz; E. W. Kuehn (2010) mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression Kidney Int.
S. Lienkamp; A. Ganner; C. Boehlke; T. Schmidt; S. J. Arnold; T. Schafer; D. Romaker; J. Schuler; S. Hoff; C. Powelske; A. Eifler; C. Kronig; A. Bullerkotte; R. Nitschke; E. W. Kuehn; E. Kim; H. Burkhardt; T. Brox; O. Ronneberger; J. Gloy; G. Walz (2010) Inversin relays Frizzled-8 signals to promote proximal pronephros development Proc Natl Acad Sci U S A 107, 20388-93.
C. Boehlke; F. Kotsis; V. Patel; S. Braeg; H. Voelker; S. Bredt; T. Beyer; H. Janusch; C. Hamann; M. Godel; K. Muller; M. Herbst; M. Hornung; M. Doerken; M. Kottgen; R. Nitschke; P. Igarashi; G. Walz; E. W. Kuehn (2010) Primary cilia regulate mTORC1 activity and cell size through Lkb1 Nat Cell Biol 12, 1115-22.
G. Walz; K. Budde; M. Mannaa; J. Nurnberger; C. Wanner; C. Sommerer; U. Kunzendorf; B. Banas; W. H. Horl; N. Obermuller; W. Arns; H. Pavenstadt; J. Gaedeke; M. Buchert; C. May; H. Gschaidmeier; S. Kramer; K. U. Eckardt (2010) Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease N Engl J Med.
T. Hermle; D. Saltukoglu; J. Grunewald; G. Walz; M. Simons (2010) Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit Curr Biol 20, 1269-76.
T. Treiber; E. M. Mandel; S. Pott; I. Gyory; S. Firner; E. T. Liu; R. Grosschedl (2010) Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin Immunity 32, 714-25.
C. Boehlke; M. Bashkurov; A. Buescher; T. Krick; A. K. John; R. Nitschke; G. Walz; E. W. Kuehn (2010) Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels J Cell Sci 123, 1460-7.
E. Neumann-Haefelin; A. Kramer-Zucker; K. Slanchev; B. Hartleben; F. Noutsou; K. Martin; N. Wanner; A. Ritter; M. Godel; P. Pagel; X. Fu; A. Muller; R. Baumeister; G. Walz; T. B. Huber (2010) A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis Hum Mol Genet 19, 2347-59.
M. Gerner; R. Haribaskar; M. Putz; J. Czerwitzki; G. Walz; T. Schafer (2010) The retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) links RPGR to the nephronophthisis protein network Kidney Int 77, 891-6.
B. Hartleben; M. Godel; C. Meyer-Schwesinger; S. Liu; T. Ulrich; S. Kobler; T. Wiech; F. Grahammer; S. J. Arnold; M. T. Lindenmeyer; C. D. Cohen; H. Pavenstadt; D. Kerjaschki; N. Mizushima; A. S. Shaw; G. Walz; T. B. Huber (2010) Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice J Clin Invest 120, 1084-96.
E. M. Mandel; R. Grosschedl (2010) Transcription control of early B cell differentiation Curr Opin Immunol 22, 161-7.
U. Schaffer; A. Schlosser; K. M. Muller; A. Schafer; N. Katava; R. Baumeister; E. Schulze (2010) SnAvi--a new tandem tag for high-affinity protein-complex purification Nucleic Acids Res 38, e91.
H. Peng; U. Lewandrowski; B. Muller; A. Sickmann; G. Walz; T. Wegierski (2010) Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel Biochem Biophys Res Commun 391, 1721-5.
G. Walz; E. Kim (2010) Wnt signaling and rejuvenation of the adult kidney Nephrol Dial Transplant 25, 34-6.
H. Gao; Y. Wang; T. Wegierski; K. Skouloudaki; M. Putz; X. Fu; C. Engel; C. Boehlke; H. Peng; E. W. Kuehn; E. Kim; A. Kramer-Zucker; G. Walz (2010) PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation Hum Mol Genet 19, 16-24.
H. Omran; N. T. Loges (2009) Immunofluorescence staining of ciliated respiratory epithelial cells Methods Cell Biol 91, 123-33.
N. T. Loges; H. Olbrich; A. Becker-Heck; K. Haffner; A. Heer; C. Reinhard; M. Schmidts; A. Kispert; M. A. Zariwala; M. W. Leigh; M. R. Knowles; H. Zentgraf; H. Seithe; G. Nurnberg; P. Nurnberg; R. Reinhardt; H. Omran (2009) Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects Am J Hum Genet 85, 883-9.
F. Savarese; A. Davila; R. Nechanitzky; I. De La Rosa-Velazquez; C. F. Pereira; R. Engelke; K. Takahashi; T. Jenuwein; T. Kohwi-Shigematsu; A. G. Fisher; R. Grosschedl (2009) Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression Genes Dev 23, 2625-38.
S. J. Arnold; J. Sugnaseelan; M. Groszer; S. Srinivas; E. J. Robertson (2009) Generation and analysis of a mouse line harboring GFP in the Eomes/Tbr2 locus Genesis 47, 775-81.
A. Ganner; S. Lienkamp; T. Schafer; D. Romaker; T. Wegierski; T. J. Park; S. Spreitzer; M. Simons; J. Gloy; E. Kim; J. B. Wallingford; G. Walz (2009) Regulation of ciliary polarity by the APC/C Proc Natl Acad Sci U S A 106, 17799-804.
R. Haribaskar; M. Putz; B. Schupp; K. Skouloudaki; A. Bietenbeck; G. Walz; T. Schafer (2009) The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9 Biochem Biophys Res Commun 387, 212-7.
O. M. Woodward; A. Kottgen; J. Coresh; E. Boerwinkle; W. B. Guggino; M. Kottgen (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout Proc Natl Acad Sci U S A 106, 10338-42.
K. Skouloudaki; M. Puetz; M. Simons; J. R. Courbard; C. Boehlke; B. Hartleben; C. Engel; M. J. Moeller; C. Englert; F. Bollig; T. Schafer; H. Ramachandran; M. Mlodzik; T. B. Huber; E. W. Kuehn; E. Kim; A. Kramer-Zucker; G. Walz (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development Proc Natl Acad Sci U S A 106, 8579-84.
H. Gao; L. K. Sellin; M. Putz; C. Nickel; M. Imgrund; P. Gerke; R. Nitschke; G. Walz; A. G. Kramer-Zucker (2009) A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum Exp Cell Res 315, 1157-70.
T. B. Huber; B. Hartleben; K. Winkelmann; L. Schneider; J. U. Becker; M. Leitges; G. Walz; H. Haller; M. Schiffer (2009) Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome J Am Soc Nephrol 20, 798-806.
J. Samann; J. Hegermann; E. von Gromoff; S. Eimer; R. Baumeister; E. Schmidt (2009) Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth J Biol Chem 284, 16482-91.
B. Rumberger; C. Kreutz; C. Nickel; M. Klein; S. Lagoutte; S. Teschner; J. Timmer; P. Gerke; G. Walz; J. Donauer (2009) Combination of immunosuppressive drugs leaves specific "fingerprint" on gene expression in vitro Immunopharmacol Immunotoxicol 31, 283-92.
T. Wegierski; D. Steffl; C. Kopp; R. Tauber; B. Buchholz; R. Nitschke; E. W. Kuehn; G. Walz; M. Kottgen (2009) TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum Embo J 28, 490-9.
W. Reichardt; D. Romaker; A. Becker; M. Buechert; G. Walz; D. von Elverfeldt (2009) Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD Magma 22, 143-9.
T. Wegierski; U. Lewandrowski; B. Muller; A. Sickmann; G. Walz (2009) Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli J Biol Chem 284, 2923-33.
D. Romaker; M. Puetz; S. Teschner; J. Donauer; M. Geyer; P. Gerke; B. Rumberger; B. Dworniczak; P. Pennekamp; B. Buchholz; H. P. Neumann; R. Kumar; J. Gloy; K. U. Eckardt; G. Walz (2009) Increased expression of secreted frizzled-related protein 4 in polycystic kidneys J Am Soc Nephrol 20, 48-56.
H. Omran; D. Kobayashi; H. Olbrich; T. Tsukahara; N. T. Loges; H. Hagiwara; Q. Zhang; G. Leblond; E. O'Toole; C. Hara; H. Mizuno; H. Kawano; M. Fliegauf; T. Yagi; S. Koshida; A. Miyawaki; H. Zentgraf; H. Seithe; R. Reinhardt; Y. Watanabe; R. Kamiya; D. R. Mitchell; H. Takeda (2008) Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins Nature 456, 611-6.
D. J. Morris-Rosendahl; J. Najm; A. M. Lachmeijer; L. Sztriha; M. Martins; A. Kuechler; V. Haug; C. Zeschnigk; P. Martin; M. Santos; C. Vasconcelos; H. Omran; U. Kraus; M. S. Van der Knaap; G. Schuierer; K. Kutsche; G. Uyanik (2008) Refining the phenotype of alpha-1a Tubulin (TUBA1A) mutation in patients with classical lissencephaly Clin Genet 74, 425-33.
N. T. Loges; H. Olbrich; L. Fenske; H. Mussaffi; J. Horvath; M. Fliegauf; H. Kuhl; G. Baktai; E. Peterffy; R. Chodhari; E. M. Chung; A. Rutman; C. O'Callaghan; H. Blau; L. Tiszlavicz; K. Voelkel; M. Witt; E. Zietkiewicz; J. Neesen; R. Reinhardt; H. M. Mitchison; H. Omran (2008) DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm Am J Hum Genet 83, 547-58.
E. Neumann-Haefelin; W. Qi; E. Finkbeiner; G. Walz; R. Baumeister; M. Hertweck (2008) SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans Genes Dev 22, 2721-35.
T. Schafer; M. Putz; S. Lienkamp; A. Ganner; A. Bergbreiter; H. Ramachandran; V. Gieloff; M. Gerner; C. Mattonet; P. G. Czarnecki; J. A. Sayer; E. A. Otto; F. Hildebrandt; A. Kramer-Zucker; G. Walz (2008) Genetic and physical interaction between the NPHP5 and NPHP6 gene products Hum Mol Genet 17, 3655-62.
M. Kottgen; B. Buchholz; M. A. Garcia-Gonzalez; F. Kotsis; X. Fu; M. Doerken; C. Boehlke; D. Steffl; R. Tauber; T. Wegierski; R. Nitschke; M. Suzuki; A. Kramer-Zucker; G. G. Germino; T. Watnick; J. Prenen; B. Nilius; E. W. Kuehn; G. Walz (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex J Cell Biol 182, 437-47.
B. Hartleben; H. Schweizer; P. Lubben; M. P. Bartram; C. C. Moller; R. Herr; C. Wei; E. Neumann-Haefelin; B. Schermer; H. Zentgraf; D. Kerjaschki; J. Reiser; G. Walz; T. Benzing; T. B. Huber (2008) Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity J Biol Chem 283, 23033-8.
Y. Luke; H. Zaim; I. Karakesisoglou; V. M. Jaeger; L. Sellin; W. Lu; M. Schneider; S. Neumann; A. Beijer; M. Munck; V. C. Padmakumar; J. Gloy; G. Walz; A. A. Noegel (2008) Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin J Cell Sci 121, 1887-98.
F. Kotsis; R. Nitschke; M. Doerken; G. Walz; E. W. Kuehn (2008) Flow modulates centriole movements in tubular epithelial cells Pflugers Arch 456, 1025-35.
X. Fu; Y. Wang; N. Schetle; H. Gao; M. Putz; G. von Gersdorff; G. Walz; A. G. Kramer-Zucker (2008) The subcellular localization of TRPP2 modulates its function J Am Soc Nephrol 19, 1342-51.
J. O. Sass; F. Jobard; M. Topcu; A. Mahfoud; E. Werle; S. Cure; N. Al-Sannaa; S. A. Alshahwan; M. Bataillard; L. Cimbalistiene; C. Grolik; V. Kemmerich; H. Omran; L. Sztriha; M. Tabache; J. Fischer (2008) L: -2-Hydroxyglutaric aciduria: Identification of ten novel mutations in the L2HGDH gene J Inherit Metab Dis.
C. Bergmann; M. Fliegauf; N. O. Bruchle; V. Frank; H. Olbrich; J. Kirschner; B. Schermer; I. Schmedding; A. Kispert; B. Kranzlin; G. Nurnberg; C. Becker; T. Grimm; G. Girschick; S. A. Lynch; P. Kelehan; J. Senderek; T. J. Neuhaus; T. Stallmach; H. Zentgraf; P. Nurnberg; N. Gretz; C. Lo; S. Lienkamp; T. Schafer; G. Walz; T. Benzing; K. Zerres; H. Omran (2008) Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia Am J Hum Genet 82, 959-70.
C. Sustmann; H. Flach; H. Ebert; Q. Eastman; R. Grosschedl (2008) Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin Mol Cell Biol 28, 3526-37.
P. Nielsen; R. Grosschedl (2008) Multitasking of interferon regulatory factor-4 in early B cells Immunity 28, 295-7.
D. Dirnberger; M. Messerschmid; R. Baumeister (2008) An optimized split-ubiquitin cDNA-library screening system to identify novel interactors of the human Frizzled 1 receptor Nucleic Acids Res 36, e37.
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